ParkinsonCanadaV1, Main, Exploration, bibRecord, 002F02

Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release. Commentary

Identifieur interne : 002F02 ( Main/Exploration ); précédent : 002F01; suivant : 002F03

Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release. Commentary

Auteurs : Aviva Abosch [Canada] ; Shitij Kapur [Canada] ; Anthony E. Lang [Canada] ; Doug Hussey [Canada] ; Elspeth Sime [Canada] ; Janis Miyasaki [Canada] ; Svlvain Houle [Canada] ; Andres M. Lozano [Canada] ; Philip Starr ; Giovanni Broggi ; Roy A. E. Bakay ; Nicholas Boulis ; Ali R. Rezai

Source :

Neurosurgery [ 0148-396X ] ; 2003.

RBID : Pascal:04-0104974

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Stimulation instrumentale, Electrique, Noyau sousthalamique, Tomoscintigraphie, Emission, Positon, Corps strié, Dopamine, Exploration, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Basal Ganglia (diagnostic imaging), Basal Ganglia (metabolism), Corpus striatum, Dopamine, Dopamine (metabolism), Dopamine Antagonists, Electric, Electric Stimulation Therapy, Emission, Emission tomography, Exploration, Female, Human, Humans, Instrumental stimulation, Male, Middle Aged, Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Parkinson Disease (therapy), Parkinson disease, Positron, Raclopride, Subthalamic Nucleus (diagnostic imaging), Subthalamic Nucleus (metabolism), Subthalamic nucleus, Tomography, Emission-Computed.
MESH :
- chemical , metabolism : Dopamine.
- diagnostic imaging : Basal Ganglia, Parkinson Disease, Subthalamic Nucleus.
- metabolism : Basal Ganglia, Parkinson Disease, Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Dopamine Antagonists, Electric Stimulation Therapy, Female, Humans, Male, Middle Aged, Raclopride, Tomography, Emission-Computed.

Abstract

OBJECTIVE: The subthalamic nucleus (STN) is a target in the surgical treatment of Parkinson's disease (PD). The mechanism by which electrical stimulation of the STN ameliorates symptoms of PD remains unknown. One consistent aspect of STN stimulation is the ability to reduce the dosage of dopaminergic medications; sometimes they can be eliminated altogether. Furthermore, nigrostriatal projection axons are apposed to the dorsal surface of the STN and are likely affected by the application of current in this region. We sought to determine whether STN stimulation could release endogenous striatal dopamine. METHODS: Five patients with PD, who had previously undergone surgical implantation of bilateral STN stimulators, underwent [¹¹C]raclopride positron emission tomographic scanning. L-dopa was withheld for 12 hours, and both stimulators were turned off 9 hours before scanning. We assayed for striatal dopamine release by measuring radioligand displacement as a consequence of turning on the right STN stimulator after 45 minutes of a 90-minute [¹¹C]raclopride infusion. Patients were evaluated with the motor section of the Unified Parkinson's Disease Rating Scale before and after the studies. RESULTS: Comparisons between the right and left striata, before and after right STN stimulation, demonstrated no significant differences in [¹¹C]raclopride binding, despite significant improvements in Unified Parkinson's Disease Rating Scale motor scores with unilateral stimulation (mean improvement, 26.0 ± 16.4%; P < 0.05). This finding was also noted when the striatum was partitioned into dorsal and ventral caudate and putamen and the four regions were analyzed separately. CONCLUSION: Our results suggest that STN stimulation does not mediate its anti-PD effects via the release of dopamine, as assessed with [¹¹C]raclopride displacement.

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release. Commentary</title>
<author><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name>
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<author><name sortKey="Kapur, Shitij" sort="Kapur, Shitij" uniqKey="Kapur S" first="Shitij" last="Kapur">Shitij Kapur</name>
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</author>
<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, Division of Neurosurgery, Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto, Ontario</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>University Health Network, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Starr, Philip" sort="Starr, Philip" uniqKey="Starr P" first="Philip" last="Starr">Philip Starr</name>
</author>
<author><name sortKey="Broggi, Giovanni" sort="Broggi, Giovanni" uniqKey="Broggi G" first="Giovanni" last="Broggi">Giovanni Broggi</name>
</author>
<author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name>
</author>
<author><name sortKey="Boulis, Nicholas" sort="Boulis, Nicholas" uniqKey="Boulis N" first="Nicholas" last="Boulis">Nicholas Boulis</name>
</author>
<author><name sortKey="Rezai, Ali R" sort="Rezai, Ali R" uniqKey="Rezai A" first="Ali R." last="Rezai">Ali R. Rezai</name>
</author>
</analytic>
<series><title level="j" type="main">Neurosurgery</title>
<title level="j" type="abbreviated">Neurosurgery</title>
<idno type="ISSN">0148-396X</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurosurgery</title>
<title level="j" type="abbreviated">Neurosurgery</title>
<idno type="ISSN">0148-396X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Basal Ganglia (diagnostic imaging)</term>
<term>Basal Ganglia (metabolism)</term>
<term>Corpus striatum</term>
<term>Dopamine</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine Antagonists</term>
<term>Electric</term>
<term>Electric Stimulation Therapy</term>
<term>Emission</term>
<term>Emission tomography</term>
<term>Exploration</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Instrumental stimulation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Positron</term>
<term>Raclopride</term>
<term>Subthalamic Nucleus (diagnostic imaging)</term>
<term>Subthalamic Nucleus (metabolism)</term>
<term>Subthalamic nucleus</term>
<term>Tomography, Emission-Computed</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Basal Ganglia</term>
<term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia</term>
<term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Dopamine Antagonists</term>
<term>Electric Stimulation Therapy</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Raclopride</term>
<term>Tomography, Emission-Computed</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Stimulation instrumentale</term>
<term>Electrique</term>
<term>Noyau sousthalamique</term>
<term>Tomoscintigraphie</term>
<term>Emission</term>
<term>Positon</term>
<term>Corps strié</term>
<term>Dopamine</term>
<term>Exploration</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">OBJECTIVE: The subthalamic nucleus (STN) is a target in the surgical treatment of Parkinson's disease (PD). The mechanism by which electrical stimulation of the STN ameliorates symptoms of PD remains unknown. One consistent aspect of STN stimulation is the ability to reduce the dosage of dopaminergic medications; sometimes they can be eliminated altogether. Furthermore, nigrostriatal projection axons are apposed to the dorsal surface of the STN and are likely affected by the application of current in this region. We sought to determine whether STN stimulation could release endogenous striatal dopamine. METHODS: Five patients with PD, who had previously undergone surgical implantation of bilateral STN stimulators, underwent [<sup>11</sup>
C]raclopride positron emission tomographic scanning. L-dopa was withheld for 12 hours, and both stimulators were turned off 9 hours before scanning. We assayed for striatal dopamine release by measuring radioligand displacement as a consequence of turning on the right STN stimulator after 45 minutes of a 90-minute [<sup>11</sup>
C]raclopride infusion. Patients were evaluated with the motor section of the Unified Parkinson's Disease Rating Scale before and after the studies. RESULTS: Comparisons between the right and left striata, before and after right STN stimulation, demonstrated no significant differences in [<sup>11</sup>
C]raclopride binding, despite significant improvements in Unified Parkinson's Disease Rating Scale motor scores with unilateral stimulation (mean improvement, 26.0 ± 16.4%; P < 0.05). This finding was also noted when the striatum was partitioned into dorsal and ventral caudate and putamen and the four regions were analyzed separately. CONCLUSION: Our results suggest that STN stimulation does not mediate its anti-PD effects via the release of dopamine, as assessed with [<sup>11</sup>
C]raclopride displacement.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name>
<name sortKey="Boulis, Nicholas" sort="Boulis, Nicholas" uniqKey="Boulis N" first="Nicholas" last="Boulis">Nicholas Boulis</name>
<name sortKey="Broggi, Giovanni" sort="Broggi, Giovanni" uniqKey="Broggi G" first="Giovanni" last="Broggi">Giovanni Broggi</name>
<name sortKey="Rezai, Ali R" sort="Rezai, Ali R" uniqKey="Rezai A" first="Ali R." last="Rezai">Ali R. Rezai</name>
<name sortKey="Starr, Philip" sort="Starr, Philip" uniqKey="Starr P" first="Philip" last="Starr">Philip Starr</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name>
</noRegion>
<name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name>
<name sortKey="Houle, Svlvain" sort="Houle, Svlvain" uniqKey="Houle S" first="Svlvain" last="Houle">Svlvain Houle</name>
<name sortKey="Houle, Svlvain" sort="Houle, Svlvain" uniqKey="Houle S" first="Svlvain" last="Houle">Svlvain Houle</name>
<name sortKey="Hussey, Doug" sort="Hussey, Doug" uniqKey="Hussey D" first="Doug" last="Hussey">Doug Hussey</name>
<name sortKey="Hussey, Doug" sort="Hussey, Doug" uniqKey="Hussey D" first="Doug" last="Hussey">Doug Hussey</name>
<name sortKey="Kapur, Shitij" sort="Kapur, Shitij" uniqKey="Kapur S" first="Shitij" last="Kapur">Shitij Kapur</name>
<name sortKey="Kapur, Shitij" sort="Kapur, Shitij" uniqKey="Kapur S" first="Shitij" last="Kapur">Shitij Kapur</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<name sortKey="Miyasaki, Janis" sort="Miyasaki, Janis" uniqKey="Miyasaki J" first="Janis" last="Miyasaki">Janis Miyasaki</name>
<name sortKey="Miyasaki, Janis" sort="Miyasaki, Janis" uniqKey="Miyasaki J" first="Janis" last="Miyasaki">Janis Miyasaki</name>
<name sortKey="Sime, Elspeth" sort="Sime, Elspeth" uniqKey="Sime E" first="Elspeth" last="Sime">Elspeth Sime</name>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release. Commentary

Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release. Commentary

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	La maladie de Parkinson au Canada (serveur d'exploration)
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